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Monday, May 11, 2020 | History

2 edition of Immunity and autoimmunity in diabetes mellitus found in the catalog.

Immunity and autoimmunity in diabetes mellitus

Immunity and autoimmunity in diabetes mellitus

proceedings of the Francqui Foundation colloquium, Brussels, April 30-May 1, 1973

  • 317 Want to read
  • 14 Currently reading

Published by Excerpta Medica, American Elsevier Pub. Co. in Amsterdam, New York .
Written in English

    Subjects:
  • Diabetes -- Immunological aspects -- Congresses.,
  • Immunity -- Congresses.,
  • Autoimmunity -- Congresses.

  • Edition Notes

    Includes bibliographies and indexes.

    Statementeditors, P. A. Bastenie, W. Gepts ; co-editor, G. M. Addison.
    SeriesInternational congress series ;, no. 316
    ContributionsBastenie, P. A., ed., Gepts, W., ed., Addison, G. M., Fondation Francqui (Belgium)
    Classifications
    LC ClassificationsRC660 .I4
    The Physical Object
    Paginationxii, 291 p. :
    Number of Pages291
    ID Numbers
    Open LibraryOL5069050M
    ISBN 100444151109
    LC Control Number74077420

    Antiinfection immunity and autoimmunity / Rolf M. Zinkernagel Viruses and diabetes / Elmar Jaeckel, Michael Manns, and Matthias von Herrath Theiler's virus-mediated autoimmunity: local presentation of CNS antigens and epitope spreading / S. Mark Tompkins, Kevin G. Fuller, and Stephen D. Miller. After the recognition of the essential role of the immune system in the progression of type 2 diabetes mellitus, more studies are focused on the effects produced by the abnormal differentiation of components of the immune system. In patients suffering from obesity or T2DM, there were alterations in proliferation of T cells and macrophages, and impairment in function of NK cells and B cells Cited by:

    You may want to learn more about how type 1a diabetes develops. We know type 1a diabetes is caused by an autoimmune process in the body that mistakenly destroys the insulin-producing cells, or beta cells and occurs in genetically predisposed individuals.   Cannabidiol (CBD), a non-psychoactive cannabidinoid has been previously shown by us to suppress cell-mediated autoimmune joint destruction in an animal model of rheumatoid arthritis. We now report that CBD treatment significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-treated control mice to an incidence Cited by:

    Immunology of Diabetes: Autoimmune Mechanisms and the Prevention and Cure of Type 1 Diabetes: Part I. Infection and Autoimmunity Antiinfection Immunity and Autoimmunity ROLF M. ZINKERNAGEL.   If type 2 diabetes is an autoimmune disease, the discovery may have big implications on our understanding of ’ll also affect the way obesity-induced type 2 diabetes is : Kimberly Holland.


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Immunity and autoimmunity in diabetes mellitus Download PDF EPUB FB2

Autoimmune diabetes mellitus (Type 1A) - Autoimmunity - NCBI Bookshelf. Autoimmune diabetes mellitus or T1DM is an organ-specific autoimmune disease that affects the insulin-producing pancreatic beta cells, after an inflammatory process leads to a chronic deficiency of Author: Andrés F. Echeverri, Gabriel J.

Tobón. In: Bastenie PA, Gepts W (eds) Immunity and autoimmunity in diabetes mellitus. Excerpta Medica, Amsterdam, pp – Google Scholar Moulias R, Goust JM, Bernard S, Croisier B, Attali A, Berthaux P () Humoral and cellular thyroid auto-immunity and diabetes : Robert Volpé, Robert Volpé.

2 Immunity and Autoimmunity in Diabetes Mellitus MORTEN CHRISTY TORSTEN DECKERT JORN NERUP The syndrome of diabetes mellitus comprises at least five distinct nosological entities as shown in Table 1. These conditions differ from one another in clinical features, genetics (see Chapter 1) (Creutzfeldt, K/Sbberling and Neel, ) and, therefore Cited by:   Therefore, he speculated that cell-mediated immunity could play an important part in the pathogenesis of T1D.

As a view suggesting that T1D is an autoimmune disease, there is some evidence that T1D is often complicated with other autoimmune diseases or that anti-islet autoantibodies precede the clinical onset of the by: Abstract.

Diabetes mellitus is a metabolic disease characterized by alterations in insulin production, insulin action, or a combination of both, leading to abnormal hyperglycemia (1–3).Diabetes is a chronic disease that has no cure and is an increasing major Immunity and autoimmunity in diabetes mellitus book health problem (4).The chronic nature of diabetes frequently leads to debilitating complications resulting primarily from Cited by: 3.

Chapter Prediction of Autoimmune Disease. TYPE 1 DIABETES Mellitus as a Model for Prediction of Autoimmune Disease. The Pancreatic Pathology in TYPE 1 Diabetes MELLITUS and Islet Autoimmunity. Laboratory Markers of Autoimmunity (Including Autoantibodies and T Cell Assays) Organ-Specific Autoimmune Diseases.

Non-Organ Specific Disease Book Edition: 5. Most studies investigating islet autoimmunity are based on islet autoantibody positivity. Using islet autoantibodies as a biomarker for islet autoimmunity for T2D, the prevalence of islet autoimmunity has been estimated to be between 5–30% [24,27,28].Cited by: Key points.

• Autoimmunity involves a misdirection of the body’s immune system against its own tissues, causing a large number of diseases. • More than 80 autoimmune diseases have so far been identified: some affect only one tissue or organ, while others are.

-Dermatomyositis - Hashimoto's thyroiditis - Diabetes mellitus. • Enumerate some autoimmune diseases that involve nervous tissue such as: Encephalomyelitides - Guillain-Barre syndrome. • Explain the mechanism of turning autoreactive T and B lymphocytes to generate autoimmune responses such as: Viral infections.

Size: 1MB. Diabetes is known to cause macrovascular complications, which are highly influenced by inflammatory cytokines associated with innate immunity It is noteworthy that inhibiting the activity of pro-inflammatory molecules prevents the early steps in atherogenesis. C.F. Verge, R.

Gianani, L. YuLate progression to diabetes and evidence for chronic β-cell autoimmunity in identical twins of patients with type 1 diabetes Diabetes, 44 (), pp. Google ScholarCited by: 2. Immunity and autoimmunity in diabetes mellitus: proceedings of the Francqui Foundation colloquium, Brussels, April May 1, Autoimmunity in Insulin-Dependent Diabetes Mellitus |0RN NERUP, M.D.

AKE LERNMARK, M.D. Gentofte, Denmork From the Steno Memorial Hospital and Hage- dorn Research Laboratory Gentofte, Denmark. Work in this laboratory was supported in part by Grant AM from the U.S. Public Health Service, and Vera and Carl)ohan Michaelsens by:   Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus Tong Zhou, 1 Zheng Hu, 2 Shuo Yang, 1 Lin Sun, 1 Zhenxiang Yu, 3 and Guixia Wang 1 Tong ZhouCited by: The Lancet Autoimmune Diabetes Mellitus HORMONE-PRODUCING tissue seems peculiarly vul- nerable to assault by autoimmune disease mech- anisms, and it is understandable that an astiological role for autoimmunity should be sought in an endocrinopathy as common as diabetes mellitus.

Primer: Immunity and Autoimmunity Massimo Pietropaolo, 1Julie M. Surhigh, Patrick W. Nelson,2 and George S.

Eisenbarth3 F or nonimmunologists, a daunting and rapidly evolving immunologic vocabulary, our incom-plete understanding of both normal and abnor-mal immune function, and multiple interrelated complex immune cellular pathways can be a Cited by: Autoimmune (type 1) diabetes (which will be referred to in this chapter as autoimmune diabetes mellitus: AI-DM) is a disease of undetermined etiology and mode of inheritance, in which genetically predisposed individuals are exposed to a group of putative environmental exposures that trigger an aggressive and selective autoimmune response against beta by: 1.

Emerging data suggest a role for autoimmunity in type 2 diabetes mellitus (T2DM). In this Perspectives, the authors discuss the nature of the immune response in diabetes mellitus Cited by: Type 1 diabetes mellitus [T1D] results from the autoimmune destruction of insulin- producing beta cells triggered by environmen tal factors (Hyoty & Taylor, ; Jun & Yoon, ).

The etiology and pathogenesis of juvenile diabetes mellitus (JDM), i. e., in sulin-dependent diabetes in nonobese individuals, are still poorly by:. The trigger that leads to the pathogenesis of type 1 diabetes is currently unknown.

It is well established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes infiltrate the pancreatic islets in a response that does not cause damage. In the second phase, which occurs only in diabetes-prone individuals and strains, autoreactive T cells acquire aggressive Cited by: Type 1a diabetes develops because the body mistakenly identifies insulin-producing cells (beta cells) as being foreign, or “non-self.” The immune system targets and ultimately destroys the beta cells, resulting in an absence of insulin and the subsequent diagnosis of diabetes.Type 2 diabetes mellitus - An autoimmune disease?

and contribute to the development of type 2 diabetes mellitus (T2DM). be involved in a putative switch from innate immunity to autoimmunity.